The Challenges of the Detection of Subclinical Keratoconus at Its Earliest Stage

Undetected subclinical keratoconus (KC) is the main risk factor for iatrogenic ectasia. Many parameters have been proposed to help differentiate normal from subclinical KC corneas. Linear discriminant analysis is a technique that models the difference between different classes of data by looking for linear combinations of variables which best explain the data. The association of surfaces elevation, corneal thickness profile and anterior curvature indices leads to the best sensitivity and specificity for the discrimination between normal and early subclinical KC corneas.